B cells in anti-tumor immunity
Together with Stephan N. Wagner, we were among the first to show that B cells are vital to the anti-tumour immunity in human melanoma. In our study we observed that depleting B cells from human melanoma patients led to a reduction of the complete anti-tumour immune response.
In this project, we investigate whether B cells have a positive anti-tumor effect in all human cancers, or whether there are cancer specific differences. Additionally, through the large-scale re-analysis of public human data, we investigate whether this effect is linked to specific B cell subtypes.