Projects

We have recently identified a novel macrophage progenitor within the adult bone marrow distinct from the monocytic lineage. This progenitor...

The dynamics of myeloid immune cells during various stages of contact hypersensitivity is underappreciated. Utilizing cutting-edge intravital...

Atopic dermatitis (AD) is one of the most prevalent chronic inflammatory skin conditions. In most patients, AD is linked to IgE sensitization to various allergens with classical...

A plethora of human disorders are initiated by overt inflammation within tissues. Utilizing complex immunological models, transgenic reporter...

Abundant neutrophils are present in various skin diseases, including classical neutrophilic dermatoses (e.g., Sweet's syndrome or Pyoderma Gangraenosum), bacterial infections...

Phages are the most abundant organisms on earth, there are currently an estimated 10³¹ different species accounting for 40% of bacterial cell death. They are highly specific...

Leishmaniasis is a disfiguring, debilitating and often lethal disease prevalent in the tropics. Unlike most pathogens, the Leishmaniaparasite co-opts the immune cells thereby subverting the immune response. A deeper understanding...

Medical genetics focuses on identifying rare mutations that have a significant impact on a small number of individuals. These variants are difficult to detect, as they are part of the...

The dermal backbone is composed of a contracting fibroblast network embedded in a dense collagenous and elastin rich extracellular matrix that they themselves produce along...

The human skin serves as the outermost physical barrier of the body, constantly interacting with the environment. The skin must withstand physical impacts while also controlling immune...

We are invested in understanding the role perivascular macrophages play in solid tumor progression and metastasis. Increasing evidence points towards functional specialization of niche-specific...

e have developed amelanotic melanoma models compatible with advanced imaging modalities for functional exploration of the immune system in...

Cancer metastasis is the reason why later stages of melanoma are closely associated with poor patient prognosis. To metastasize, cells migrate from the initial tumor into...

We have recently developed a high-throughput, high-content screening platform and image analysis pipeline for measuring invasive capacity of cancer cells. Utilizing this platform....