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Projects

Deciphering macrophage ontogeny in health and disease

We have recently identified a novel macrophage progenitor within the adult bone marrow distinct from the monocytic lineage. This progenitor...

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Understanding the role of innate immune cells during contact hypersensitivity

The dynamics of myeloid immune cells during various stages of contact hypersensitivity is underappreciated. Utilizing cutting-edge intravital...

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Allergen molecules in allergic skin disease: From pathomechanisms to diagnosis and treatment

Atopic dermatitis (AD) is one of the most prevalent chronic inflammatory skin conditions. In most patients, AD is linked to IgE sensitization to various allergens with classical...

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Delineating the role of innate immune cells in leukocyte trafficking during sterile inflammation.

A plethora of human disorders are initiated by overt inflammation within tissues. Utilizing complex immunological models, transgenic reporter...

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Dissecting neutrophil heterogeneity and function in cutaneous inflammatory diseases

Abundant neutrophils are present in various skin diseases, including classical neutrophilic dermatoses (e.g., Sweet's syndrome or Pyoderma Gangraenosum), bacterial infections...

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Skin phageome

Phages are the most abundant organisms on earth, there are currently an estimated 1031 different species accounting for 40% of bacterial cell death. They are highly specific...

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Understanding the interplay of Leishmania and host immune cells

Leishmaniasis is a disfiguring, debilitating and often lethal disease prevalent in the tropics. Unlike most pathogens, the Leishmaniaparasite co-opts the immune cells thereby subverting the immune response. A deeper understanding...

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Medical Genomics

Medical genetics focuses on identifying rare mutations that have a significant impact on a small number of individuals. These variants are difficult to detect, as they are part of the...

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Dermal tissue mechanics and lymphatic function in homeostasis and inflammation

The dermal backbone is composed of a contracting fibroblast network embedded in a dense collagenous and elastin rich extracellular matrix that they themselves produce along...

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ECM modifications in inflammatory skin diseases

The human skin serves as the outermost physical barrier of the body, constantly interacting with the environment. The skin must withstand physical impacts while also controlling immune...

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Elucidating the role of perivascular macrophages in breast cancer development and metastasis

We are invested in understanding the role perivascular macrophages play in solid tumor progression and metastasis. Increasing evidence points towards functional specialization of niche-specific...

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Imaging dynamics of immune cells in the melanoma tumour microenvironment

e have developed amelanotic melanoma models compatible with advanced imaging modalities for functional exploration of the immune system in...

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Investigating the role of the extracellular matrix to induce “pioneer melanoma cells”

Cancer metastasis is the reason why later stages of melanoma are closely associated with poor patient prognosis. To metastasize, cells migrate from the initial tumor into...

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Novel High-throughput Screening Platform for Drug-Discovery

We have recently developed a high-throughput, high-content screening platform and image analysis pipeline for measuring invasive capacity of cancer cells. Utilizing this platform....

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