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Immune cell dynamics in melanoma

Imaging dynamics of immune cells in the melanoma tumour microenvironment


We have developed amelanotic melanoma models compatible with advanced imaging modalities for functional exploration of the immune system in immunocompetent mice. Utilizing cutting-edge intravital, multiphoton microscopy and light-sheet imaging, we can decipher the immune cell dynamics and localization at a single-cell resolution.

  • Shweta Tikoo, Rohit Jain, Florence Tomasetig, Kathy On, Brendon Martinez, Celine Heu, Daniel Stehle, Peyman Obeidy, Dajiang Guo, Jonathan N. Vincent, Adam J.L. Cook, Ben Roediger, Robert Feil, Renee M. Whan and Wolfgang Weninger. Amelanotic B16-F10 melanoma compatible with advanced three-dimensional imaging modalities.  J Invest Dermatol. 2021 141, 2090-2094 e2096

People involved in the project: Shweta Tikoo, Rohit Jain